一、研究方向

　　1. 饲料及工业用酶

　　定位于饲料及工业用酶领域的基础研究和产品开发，以促进饲料及工业用酶的产业升级、推广应用为目标。在酶资源挖掘和利用、酶结构和功能研究和催化机理解析、酶高效分泌表达研究基础上，重点发展生物信息预测技术、功能基因大数据挖掘技术、计算辅助的酶定向设计和改良技术、人工酶技术、新的表达体系等，致力于重要生物资源及酶相关的元件的发掘和鉴定、重要酶分子改造、显著提高酶的异源表达水平、提高酶制剂的规模化生产和应用水平，为酶制剂产业提供核心技术支撑。

　　2. 畜牧业用生物活性制剂研究

　　在生物活性产物的生物合成、代谢调控、作用机制、结构功能等研究的基础上，阐明生物活性作用机制，利用合成生物学的理念和技术方法，重点发展基因组工程、代谢途径工程、进化工程等，优化、重排或理性设计微生物细胞代谢途径，打通从基因组到产品的技术链条，大量合成功能性蛋白和畜牧业用生物活性物质，发展畜牧业用生物活性高效生产平台。提高畜牧业用生物活性物质的产率与效率，实现重点新产品创制。

　　二、代表性成果

　　1． 科技奖励与成果转化

　　获国家科技进步二等奖2项，省部级一等奖1项，发明专利优秀奖4项。

　　研发的二十余种饲料酶和工业酶产品已实现产业化生产，并成为市场上的主导产品和先导产品。获得中国发明专利和国际发明专利100余项，其中专利许可/技术转让 40余项。确立了在饲用酶制剂理论及应用研究方面的国际先进水平，并在我国饲料行业起到了很好的示范推广作用。

　　2. 代表性论文

　　Ge Jianzhong, Jiang Xiao Liu Weina, Wang Yuan, Huang Huoqing, Bai Yingguo, Su Xiaoyun, Yao Bin *, Luo Huiying*. Characterization, stability improvement, and bread baking applications of a novel cold-adapted glucose oxidase from Cladosporium neopsychrotolerans SL16. Food Chem. 2020, 310:125970

　　Yu Xinrui #, Tu Tao #, Luo Huiying, Huang Huoqing, Su Xiaoyun, Wang Yuan, Wang Yaru, Zhang Jie, Bai Yingguo *, Yao Bin *. Biochemical characterization and mutational analysis of a lactone hydrolase from Phialophora americana . J Agric Food Chem. 2020, 68(8):2570-2577.

　　Zheng Fei #, Josh V. Vermaas#, Zheng Jie, Wang Yuan, Tu Tao, Wang Xiaoyu, Xie Xiangming, Yao Bin, Gregg T. Beckham*, Luo Huiying *. Characterizing activity and thermostability of GH5 endoglucanase chimeras from mesophilic and thermophilic parents. Appl Environ Microbiol. 2019,85(5): e02079-18

　　Wang Xiaolu ‡, Qin Xing ‡, Hao Zhenzhen, Luo Huiying, Yao Bin *, Su Xiaoyun *. Degradation of four major mycotoxins by eight manganese peroxidases in presence of a dicarboxylic acid. Toxins 2019,11:566.

　　Guo Yujie, Tu Tao, Zheng Jie, Bai Yingguo, Huang Huoqing, Su Xiaoyun, Wang Yuan, Wang Yaru, Yao Bin *, Luo Huiying *. Improvement of BsAPA aspartic protease thermostability via autocatalysis-resistant mutation. J Agric Food Chem. 2019, 67(37):10505-10512.

　　Liu Weina #, Tu Tao #, Gu Yuan, Wang Yuan, Zheng Fei, Zheng Jie, Wang Yaru, Su Xiaoyun, Yao Bin *, Luo Huiying *. Insight into the thermophilic mechanism of a glycoside hydrolase family 5 β-mannanase. J Agric Food Chem. 2019, 67(1): 473-483

　　Guo Yujie, Tu Tao, Yuan Peng, Wang Yuan, Ren Yaxin, Yao Bin *, Luo Huiying *. High-level expression and characterization of a novel aspartic protease from Talaromyces leycettanus JCM12802 and its potential application in juice clarification. Food Chem. 2019, 281:197-203.

　　Wang Hui, Zhang Xin, Qiu Jin, Wang Kaikai, Meng Kun, Luo Huiying, Su Xiaoyun, Ma Rui, Huang Huoqing*, Yao Bin*. Development of Bacillus amyloliquefaciens as a high-level recombinant protein expression system. J Ind Microbiol Biotechnol. 2019, 46(1):113-123.

　　Qin Xing, Luo Huiying, Zhang Xiaoyu, Yao Bin, Ma Fuying *, Su Xiaoyun *. Dye-decolorizing peroxidases in Irpex lacteus combining the catalytic properties of heme peroxidases and laccase play important roles in ligninolytic system. Biotechnol Biofuels. 2018,11: 302.

　　Gao Fei, Hao Zhenzhen, Sun Xianhua, Qin Lina, Zhao Tong, Liu Weiquan, Luo Huiying, Yao Bin, Su Xiaoyun. A versatile system for fast screening and isolation of Trichoderma reesei cellulose hyperproducers based on DsRed and fluorescence-assisted cell sorting. Biotechnol Biofuels. 2018, 11:261.

　　Sun Xianhua, Xue Xianli, Li Mengzhu, Gao Fei, Hao Zhenhen, Huang Huoqing, Luo Huiying, Qin Lina, Yao Bin*, Su Xiaoyun*. Efficient coproduction of mannanase and cellulase by the transformation of a codon-optimized endomannanase gene from Aspergillus niger into Trichoderma reesei. J Agric Food Chem. 2017, 65(50):11046-11053.

　　Yang Hong†, Shi Pengjun†, Liu Yun, Xia Wei, Wang Xiaoyu, Cao Huifang, Ma Rui, Luo Huiying, Bai Yingguo*, Yao Bin*. The loop 3 of fungal endoglucanases of glycoside hydrolase family 12 modulates the catalytic efficiency. Appl Environ Microbiol. 2017, 83(6): e03123-16.

　　Ma Rui, Bai Yingguo, Huang Huoqing, Luo Huiying, Chen Sanfeng, Fan Yunliu, Cai Lie, Yao Bin*. Utility of thermostable xylanases of Mycothermus thermophilus in generating prebiotic xylooligosaccharides. J Agric Food Chem. 2017, 65(6): 1139-1145.

　　Zhang Duoduo#, Tu Tao#, Wang Yuan, Li Yeqing, Luo Xuegang, Zheng Fei, Wang Xiaoyu, Bai Yingguo, Huang Huoqing, Su Xiaoyun, Yao Bin, Zhang Tongcun*, Luo Huiying*. Improvement of the catalytic performance of a Talaromyces leycettanus α-amylase by changing the linker length. J Agric Food Chem. 2017, 65(24):5041-5048

　　Chu Yindi, Tu Tao, Penttinen Leena, Xue Xianli, Wang Xiaoyu, Yi Zhuolin, Gong Li, Rouvinen Juha, Luo Huiying, Hakulinen Nina*, Yao Bin*, Su Xiaoyun*. Insights into the roles of non-catalytic residues in the active site of a GH10 xylanase with activity on cellulose. J Biol Chem. 2017, 292(47):19315-19327

　　Xia Wei, Xu Xinxin, Qian Lichun, Shi Pengjun, Bai Yingguo, Luo Huiying, Ma Rui, Yao Bin*. Engineering a highly active thermophilic β-glucosidase to enhance its pH stability and saccharification performance. Biotechnol Biofuels. 2016,9:147

　　Xue Xianli, Wu Yilan, Qin Xing, Ma Rui, Luo Huiying, Su Xiaoyun*, Yao Bin*. Revisiting overexpression of a heterologous β-glucosidase in Trichoderma reesei : fusion expression of the Neosartorya fischeri Bgl3A to cbh1 enhances the overall as well as individual cellulase activities. Microb Cell Fact. 2016,15(1):122

　　Yang Lian†, Wang Hui†, Lv Yi, Bai Yingguo, Luo Huiying, Shi Pengjun, Huang Huoqing*, Yao Bin*. Construction of a rapid feather-degrading bacterium by overexpression of a highly efficient alkaline keratinase in its parent strain Bacillus amyloliquefaciens K11. J Agric Food Chem. 2016, 64(1):78-84.

　　You Shuai, Tu Tao, Zhang Lujia, Wang Yuan, Huang Huoqing, Ma Rui, Shi Pengjun, Bai Yingguo, Su Xiaoyun, Lin Zhemin*, Luo Huiying*, Yao Bin*. Improvement of the thermostability and catalytic efficiency of a highly active β-glucanase from Talaromyces leycettanus JCM12802 by optimizing residual charge-charge interactions. Biotechnol Biofuels. 2016, 9:124.

　　Xia Wei, Lu Haiqiang, Xia Mengjuan, Cui Ying, Bai Yingguo, Qian Lichun, Shi Pengjun*, Luo Huiying, Yao Bin*. A novel glycoside hydrolase family 113 endo-β-1,4-Mannanase from Alicyclobacillus sp. strain A4 and insight into the substrate recognition and catalytic mechanism of this family. Appl Environ Microbiol. 2016, 82(9):2718-2727.

　　三、创新团队成员

　　研究团队现任首席科学家为姚斌院士，执行首席罗会颖研究员。团队现有成员60余人，其中研究员6名，副研究员4名，助理研究员4名，技术支撑人员20名，博士后2名，博士生7名，硕士生20名。团队入选“全国农业科研杰出人才及其创新团队”、“科技部重点领域创新团队”，获得国家及省部级人才称号15人次。

团队首席：姚斌      执行首席：罗会颖

骨干：黄火清、柏映国、于会民、苏小运、王亚茹、张杰、王苑、涂涛、张红莲、田健、赵勇

助理：王晓璐、秦星