个人信息

    田健，男，河北省石家庄人，博士，研究员，博士生导师。主要研究方向为蛋白智能分子设计，致力于构建人工智能与酶蛋白相结合的蛋白智能分子设计平台，提升酶蛋白的稳定性、表达量、催化活性等应用性能，提升其产业价值。

    先后主持国家重点研发政府间国际合作项目、国家重点研发计划课题、国家自然科学基金项目等多项国家及省部级项目（课题），累计发表SCI论文70余篇，其中第一或通讯作者（含共同）发表SCI论文41篇；以主要完成人身份获得授权发明专利20件（第一完成人获授权发明专利9件），软件著作权13项。2022年率团队荣获昇腾AI创新大赛区域赛金奖和全国赛银奖，获第四届范云六院士青年科技创新奖。

　　在研项目

        1、国家自然科学基金重大项目，2025-2029，课题负责人

        2、“十四五”国家重点研发计划政府间国际科技创新合作重点专项，2023-2025，项目负责人

        3、“十四五”国家重点研发计划课题，2022-2024，课题负责人

　　代表性论文

    1.Tuoyu Liu, Yiyang Zhang, Yanjun Li, Guoshun Xu, Han Gao, Pengtao Wang, Tao Tu, Huiying Luo, Ningfeng Wu, Bin Yao, Bo Liu*, Feifei Guan*, Huoqing Huang*, Jian Tian*(Corresponding author). Effective gene expression prediction and optimization from protein sequences. Advanced Science. 2025.

    2.Li, Lijian#, Tian, Jian#, Huang, K., Xue, X., Chen, J., Guan, F., Zhang, T., Sun, Y., He, C., Zeng, Xibai, Su, Shiming*. Metal-Binding Protein TaGlo1 Improves Fungal Resistance to Arsenite (As(III)) and Methylarsenite (MAs(III)) in Paddy Soil. Environ Sci Technol. 2024. 58(17):7469-7479

    3.Miao, Ruiju, Xu, Guoshun, Ding, Yekun, Ding, Zundan, Woodard, J., Tu, Tao, Luo, Huiying., Wu, Ningfeng, Yao, Bin, Guan, Feifei*, Tian, Jian*(Corresponding author). Engineering dual-functional and thermophilic BMHETase for efficient degradation of polyethylene terephthalate. Bioresour Technol 2024. 414:131556.

    4.Liu, Hanqing#, Guan, Feifei#, Liu, Tuoyu#, Yang, Lixin#, Fan, Lingxi, Liu, Xiaoqing, Luo, Huiying, Wu, Ningfeng, Yao, Bin, Tian, Jian*(Corresponding author), Huang, Huoqing*: MECE: a method for enhancing the catalytic efficiency of glycoside hydrolase based on deep neural networks and molecular evolution. Science Bulletin 2023, 68:2793-2805

    5.Liu, Tuoyu, Gao, Han, Ren, Xiaopu, Xu, Guoshun, Liu, Bo, Wu, Ningfeng, Luo, Huiying, Wang, Yuan, Tu Tao, Yao, Bin, Huang, Huoqing*, Tian, Jian*(Corresponding author): Protein-protein interaction and site prediction using transfer learning. Brief Bioinform 2023, 24(6).

              6.Ding, Zundan#, Xu, Guoshun#, Miao, Ruiju, Wu, Ningfeng, Zhang, Wei, Yao, Bin, Guan, Feifei, Huang, Huoqing*, Tian, Jian*, 2023. Rational redesign of thermophilic PET hydrolase LCCICCG to enhance hydrolysis of high crystallinity polyethylene terephthalates. J Hazard Mater 453, 131386. https://doi.org/10.1016/j.jhazmat.    2023.131386.

                 7.Meng, Xiangxi#, Yang, Lixin#, Liu, Hanqing#, Li, Qingbin, Xu, Guoshun, Zhang, Yan, Guan, Feifei, Zhang, Yuhong, Zhang, Wei, Wu, Ningfeng*, Tian, Jian*. Protein engineering of stable IsPETase for PET plastic degradation by Premuse. Int J Biol Macromol. 2021 Jun 1;180:667-676.

                 8.Guan, Feifei#; Han, Yanshuo#; Yan, Kai; Zhang, Yan; Zhang, Zhifang; Wu, Ningfeng*; Tian, Jian*; Highly efficient production of chitooligosaccharides by enzymes mined directly from the marine metagenome., Carbohydrate Polymers, 2020, 234: 115909.

9. Zhang, Pingxian, Wang, Yifan, Chachar, Sadaruddin, Tian, Jian* and Gu, Xiaofeng* (2020) eRice: a refined epigenomic platform for japonica and indica rice. Plant biotechnology journal, 18, 1642-1644.

                 10.Tian, Jian#，Woodard, Jaie#，Whitney, Anna，Shakhnovich, Eugene(*)，Thermal Stabilization of Dihydrofolate Reductaseusing Monte Carlo Unfolding Simulations and its Functional Consequences，PLoS Computational Biology, 2015, 2015, 11(4):e1004207.

                 11.Tian, Jian, Wang, Ping, Gao, Shan, Chu, Xiaoyu, Wu, Ningfeng*, Fan, Yunliu: Enhanced thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 by rationally engineering a glycine to proline mutation. FEBS Journal 2010, 277:4901-4908.

                 12.Tian, Jian, Wu, Ningfeng*, Li, Jiang, Liu, Yajie, Guo, Jun, Yao, Bin*, Fan, Yunliu: Nickel-resistant determinant from Leptospirillum ferriphilum. Applied and environmental microbiology 2007, 73(7):2364-2368.