个人信息

田健，男，河北省石家庄人，博士，研究员，博士生导师。主要研究方向为蛋白智能分子设计，致力于构建人工智能与酶蛋白相结合的蛋白智能分子设计平台，提升酶蛋白的稳定性、表达量、催化活性等应用性能，提升其产业价值。

先后主持国家重点研发政府间国际合作项目、国家重点研发计划课题、国家自然科学基金项目等多项国家及省部级项目（课题），累计发表SCI论文70余篇，其中第一或通讯作者（含共同）发表SCI论文41篇；以主要完成人身份获得授权发明专利20件（第一完成人获授权发明专利9件），软件著作权13项。2022年率团队荣获昇腾AI创新大赛区域赛金奖和全国赛银奖，获第四届范云六院士青年科技创新奖。

在研项目

1、国家自然科学基金重大项目，2025-2029，课题负责人

2、“十四五”国家重点研发计划政府间国际科技创新合作重点专项，2023-2025，项目负责人

3、“十四五”国家重点研发计划课题，2022-2024，课题负责人

代表性论文

1.Tuoyu Liu, Yiyang Zhang, Yanjun Li, Guoshun Xu, Han Gao, Pengtao Wang, Tao Tu, Huiying Luo, Ningfeng Wu, Bin Yao, Bo Liu*, Feifei Guan*, Huoqing Huang*, Jian Tian*(Corresponding author). Effective gene expression prediction and optimization from protein sequences. Advanced Science. 2025. DOI: 10.1002/advs.202407664.

2.Li, Lijian#, Tian, Jian#, Huang, K., Xue, X., Chen, J., Guan, F., Zhang, T., Sun, Y., He, C., Zeng, Xibai, Su, Shiming*. Metal-Binding Protein TaGlo1 Improves Fungal Resistance to Arsenite (As(III)) and Methylarsenite (MAs(III)) in Paddy Soil. Environ Sci Technol. 2024. 58(17):7469-7479.

3.Miao, Ruiju, Xu, Guoshun, Ding, Yekun, Ding, Zundan, Woodard, J., Tu, Tao, Luo, Huiying., Wu, Ningfeng, Yao, Bin, Guan, Feifei*, Tian, Jian*(Corresponding author). Engineering dual-functional and thermophilic BMHETase for efficient degradation of polyethylene terephthalate. Bioresour Technol 2024. 414:131556.

4.Liu, Hanqing#, Guan, Feifei#, Liu, Tuoyu#, Yang, Lixin#, Fan, Lingxi, Liu, Xiaoqing, Luo, Huiying, Wu, Ningfeng, Yao, Bin, Tian, Jian*(Corresponding author), Huang, Huoqing*: MECE: a method for enhancing the catalytic efficiency of glycoside hydrolase based on deep neural networks and molecular evolution. Science Bulletin 2023, 68:2793-2805.

5.Liu, Tuoyu, Gao, Han, Ren, Xiaopu, Xu, Guoshun, Liu, Bo, Wu, Ningfeng, Luo, Huiying, Wang, Yuan, Tu Tao, Yao, Bin, Huang, Huoqing*, Tian, Jian*(Corresponding author): Protein-protein interaction and site prediction using transfer learning. Brief Bioinform 2023, 24(6).

6.Ding, Zundan#, Xu, Guoshun#, Miao, Ruiju, Wu, Ningfeng, Zhang, Wei, Yao, Bin, Guan, Feifei, Huang, Huoqing*, Tian, Jian*, 2023. Rational redesign of thermophilic PET hydrolase LCCICCG to enhance hydrolysis of high crystallinity polyethylene terephthalates. J Hazard Mater 453, 131386. https://doi.org/10.1016/j.jhazmat.2023.131386.

7.Meng, Xiangxi#, Yang, Lixin#, Liu, Hanqing#, Li, Qingbin, Xu, Guoshun, Zhang, Yan, Guan, Feifei, Zhang, Yuhong, Zhang, Wei, Wu, Ningfeng*, Tian, Jian*. Protein engineering of stable IsPETase for PET plastic degradation by Premuse. Int J Biol Macromol. 2021 Jun 1;180:667-676.

8.Guan, Feifei#; Han, Yanshuo#; Yan, Kai; Zhang, Yan; Zhang, Zhifang; Wu, Ningfeng*; Tian, Jian*; Highly efficient production of chitooligosaccharides by enzymes mined directly from the marine metagenome., Carbohydrate Polymers , 2020, 234: 115909.

9.Zhang, Pingxian, Wang, Yifan, Chachar, Sadaruddin, Tian, Jian* and Gu, Xiaofeng* (2020) eRice: a refined epigenomic platform for japonica and indica rice. Plant biotechnology journal , 18, 1642-1644.

10.Tian, Jian#，Woodard, Jaie#，Whitney, Anna，Shakhnovich, Eugene(*)，Thermal Stabilization of Dihydrofolate Reductaseusing Monte Carlo Unfolding Simulations and its Functional Consequences， PLoS Computational Biology , 2015, 2015, 11(4):e1004207.

11.Tian, Jian, Wang, Ping, Gao, Shan, Chu, Xiaoyu, Wu, Ningfeng*, Fan, Yunliu: Enhanced thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 by rationally engineering a glycine to proline mutation. FEBS Journal 2010, 277:4901-4908.

12.Tian, Jian, Wu, Ningfeng*, Li, Jiang, Liu, Yajie, Guo, Jun, Yao, Bin*, Fan, Yunliu: Nickel-resistant determinant from Leptospirillum ferriphilum. Applied and environmental microbiology 2007, 73(7):2364-2368.

English Version:

Tian Jian, male from Shijiazhuang, Hebei Province, is a professor and doctoral supervisor. His main research focus is on intelligent protein molecular design, aiming to build a protein intelligent molecular design platform that combines artificial intelligence with enzyme proteins to enhance the stability, expression level, catalytic activity, and other application performance of enzyme proteins, thereby increasing their industrial value. He has led several national and provincial projects, including government international cooperation projects, national key R&D programs, and National Natural Science Foundation projects. He has published over 70 SCI papers, with 41 as the first or corresponding author. He has been granted 20 invention patents (9 as the first inventor) and holds 13 software copyrights. In 2022, his team won the gold award in the regional competition and the silver award in the national competition of the Rising AI Innovation Competition, and he was awarded the 4th Fan Yun Youth Science and Technology Innovation Award.

Publications

1.Tuoyu Liu, Yiyang Zhang, Yanjun Li, Guoshun Xu, Han Gao, Pengtao Wang, Tao Tu, Huiying Luo, Ningfeng Wu, Bin Yao, Bo Liu*, Feifei Guan*, Huoqing Huang*, Jian Tian*(Corresponding author). Effective gene expression prediction and optimization from protein sequences. Advanced Science. 2025.

2.Li, Lijian#, Tian, Jian#, Huang, K., Xue, X., Chen, J., Guan, F., Zhang, T., Sun, Y., He, C., Zeng, Xibai, Su, Shiming*. Metal-Binding Protein TaGlo1 Improves Fungal Resistance to Arsenite (As(III)) and Methylarsenite (MAs(III)) in Paddy Soil. Environ Sci Technol. 2024. 58(17):7469-7479

3.Miao, Ruiju, Xu, Guoshun, Ding, Yekun, Ding, Zundan, Woodard, J., Tu, Tao, Luo, Huiying., Wu, Ningfeng, Yao, Bin, Guan, Feifei*, Tian, Jian*(Corresponding author). Engineering dual-functional and thermophilic BMHETase for efficient degradation of polyethylene terephthalate. Bioresour Technol 2024. 414:131556.

4.Liu, Hanqing#, Guan, Feifei#, Liu, Tuoyu#, Yang, Lixin#, Fan, Lingxi, Liu, Xiaoqing, Luo, Huiying, Wu, Ningfeng, Yao, Bin, Tian, Jian*(Corresponding author), Huang, Huoqing*: MECE: a method for enhancing the catalytic efficiency of glycoside hydrolase based on deep neural networks and molecular evolution. Science Bulletin 2023, 68:2793-2805

5.Liu, Tuoyu, Gao, Han, Ren, Xiaopu, Xu, Guoshun, Liu, Bo, Wu, Ningfeng, Luo, Huiying, Wang, Yuan, Tu Tao, Yao, Bin, Huang, Huoqing*, Tian, Jian*(Corresponding author): Protein-protein interaction and site prediction using transfer learning. Brief Bioinform 2023, 24(6).

6.Ding, Zundan#, Xu, Guoshun#, Miao, Ruiju, Wu, Ningfeng, Zhang, Wei, Yao, Bin, Guan, Feifei, Huang, Huoqing*, Tian, Jian*, 2023. Rational redesign of thermophilic PET hydrolase LCCICCG to enhance hydrolysis of high crystallinity polyethylene terephthalates. J Hazard Mater 453, 131386. https://doi.org/10.1016/j.jhazmat.2023.131386.

7.Meng, Xiangxi#, Yang, Lixin#, Liu, Hanqing#, Li, Qingbin, Xu, Guoshun, Zhang, Yan, Guan, Feifei, Zhang, Yuhong, Zhang, Wei, Wu, Ningfeng*, Tian, Jian*. Protein engineering of stable IsPETase for PET plastic degradation by Premuse. Int J Biol Macromol. 2021 Jun 1;180:667-676.

8.Guan, Feifei#; Han, Yanshuo#; Yan, Kai; Zhang, Yan; Zhang, Zhifang; Wu, Ningfeng*; Tian, Jian*; Highly efficient production of chitooligosaccharides by enzymes mined directly from the marine metagenome., Carbohydrate Polymers , 2020, 234: 115909.

9.Zhang, Pingxian, Wang, Yifan, Chachar, Sadaruddin, Tian, Jian* and Gu, Xiaofeng* (2020) eRice: a refined epigenomic platform for japonica and indica rice. Plant biotechnology journal , 18, 1642-1644.

10.Tian, Jian#，Woodard, Jaie#，Whitney, Anna，Shakhnovich, Eugene(*)，Thermal Stabilization of Dihydrofolate Reductaseusing Monte Carlo Unfolding Simulations and its Functional Consequences， PLoS Computational Biology , 2015, 2015, 11(4):e1004207.

11.Tian, Jian, Wang, Ping, Gao, Shan, Chu, Xiaoyu, Wu, Ningfeng*, Fan, Yunliu: Enhanced thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 by rationally engineering a glycine to proline mutation. FEBS Journal 2010, 277:4901-4908.

12.Tian, Jian, Wu, Ningfeng*, Li, Jiang, Liu, Yajie, Guo, Jun, Yao, Bin*, Fan, Yunliu: Nickel-resistant determinant from Leptospirillum ferriphilum. Applied and environmental microbiology 2007, 73(7):2364-2368.

联系方式（e-mail）： tianjian@caas.cn