一、研究方向

　　1、猪优良种质特性遗传机理研究及分子标记开发

　　相比引进猪种，我国地方猪种肉品质好、繁殖性能高、耐粗饲等和外种猪的生长速度快、瘦肉率高等优良种质特性。本创新团队将利用全基因组重测序，通过全基因组关联研究、全基因组甲基化研究、RNA组学、蛋白质组学等高通量新技术，进行优良种质性状关键基因的精细定位，精确地解析其形成的遗传学机理，开发准确有效、具有育种应用价值的遗传标记，为我国猪分子育种工作的决策和顺利开展提供技术支撑。

　　2、全基因组选择选择方法研究和平台构建

　　近年来，猪基因组选择育种新技术已在全世界范围开展大规模应用，也为我国猪育种赶超世界猪育种大国提供了技术契机。本创新团队将以商业猪种为研究材料，与国内知名猪育种龙头企业合作，针对生长速度、饲料利用效率等重要经济性状，建立大规模的全基因组选择参考群体，开展基因组选育育种技术研发与应用，建立可用于商业化选育的猪全基因组选择平台，为我国猪全基因组育种工作的开展提供应用平台和技术推动力。

　　3、国产化优质猪新品种（系）培育

　　我国地方猪种肉质优良，但群体规模小，商业杂交利用效率低。为了更好地开发利用我国地方猪种资源，本创新团队将以地方猪种和引进猪种为育种素材，联合地方企事业单位及种猪场，以肉品质性状为重点，开展配合力测定及杂种优势测定，筛选最佳杂交方式，组建新品种培育核心群，经过世代选育，培育国产化优质猪新品种，为我国猪“国产化”育种工作提供理论基础和示范应用。

　　二、代表性成果

　　1、Liang J, Zhang Y, Wang L, Liu X, Yan H, Wang L, Zhang L. Molecular cloning of WIF1 and HMGA2 reveals ear-preferential expression while uncovering a missense mutation associated with porcine ear size in WIF1. Anim Genet 50:157-161. 2019.

　　2、Zhang Y, Zhang L, Yue J, Wei X, Wang L, Liu X, Gao H, Hou X, Zhao F, Yan H, Wang L. Genome-wide identification of RNA editing in seven porcine tissues by matched DNA and RNA high-throughput sequencing. J Anim Sci Biotech 10:24. 2019.

　　3、Liu X, Gong J, Wang L, Hou X, Gao H, Yan H, Zhao F, Zhang L, Wang L. Genome-Wide Profiling of the Microrna Transcriptome Regulatory Network to Identify Putative Candidate Genes Associated with Backfat Deposition in Pigs. Animals (Basel). 9(6):E313. 2019.

　　4、Zhang T, Gao H, Sahana G, Zan Y, Fan H, Liu J, Shi L, Wang H, Du L, Wang L, Zhao F. Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep. J Anim Breed Genet. 136(5):362-370. 2019.

　　5、Wang L, Zhao L, Zhang L, Liu X, Hou X, Gao H, Yan H, Zhao F, Wang L. NTN1 Affects Porcine Intramuscular Fat Content by Affecting the Expression of Myogenic Regulatory Factors. Animals (Basel). 9(9). pii: E609. 2019.

　　6、Wang L, Zhang Y, Zhang T, Zhang L, Yan H, Liu X and Wang L. Genotyping by sequencing reveals a new locus for pig teat number. Anim Genet. 48:470-472. 2017.

　　7、Zhang LC, Yue JW, Pu L, Wang LG, Liu X, Liang J, Yan H, Zhao KB, Li N, Shi HB, Zhang YB, Wang LX. Genome-wide study refines the quantitative trait locus for number of ribs in a Large White × Minzhu intercross pig population and reveals a new candidate gene. Mol Genet Genomics 291:1885-1890. 2016.

　　8、Liang J, Li N, Zhang LC, Wang LG, Liu X, Zhao KB, Yan H, Pu L, Zhang YB, Shi HB, Zhang Q, Wang LX. Porcine LEM domain-containing 3: Molecular cloning, functional characterization, and polymorphism associated with ear size. J Integrat Agri. 15(6): 1321-1329. 2016

　　9、Zhang T, Wang LG, Shi HB, Yan H, Zhang LC, Liu X, Pu L, Liang J, Zhang YB, Zhao KB, Wang LX. Heritabilities and genetic and phenotypic correlations of litter uniformity and litter size in Large White sows. J Integrat Agri. 15(4): 848–854. 2016

　　10、Zhang Y, Zhang L, Wang L, Qiao L, Liang J, Yan H, Zhao K, Liu X, Wang L. Identification and examination of a novel 9-bp insert/deletion polymorphism on porcine SFTPA1 exon 2 associated with acute lung injury using an oleic acid-acute lung injury model. Anim Sci J 86(6):573-578. 2015

　　11、Zhang YB, Liang J, Zhang LC, Wang LG, Liu X, Yan H, Zhao KB, Shi HB, Zhang T, Li N, Pu L, Wang LX. Porcine methionine sulfoxide reductase B3: molecular cloning, tissue-specific expression profiles, and polymorphisms associated with ear size in Sus scrofa. J Anim Sci Biotech. 6:60. 2015.

　　12、Zhang L, Liu X, Liang L, Yan H, Zhao KB, Li N, Pi L, Shi HB, Zhang YB, Wang LG, Wang LX. Quantitative trait loci for the number of vertebrae on Sus scrofa chromosomes 1 and 7 independently influence the numbers of thoracic and lumbar vertebrae in pigs. J Integr Agr 14: 2027-2033. 2015.

　　13、Wang LG, Xu LY, Liu X, Zhang T, Li N, Hay EL, Zhang YB, Yan H, Zhao KB, Liu, GE, Zhang LC, Wang LX. Copy number variation-based genome wide association study reveals additional variants contributing to meat quality in Swine. Sci Rep 5:12535. 2015.

　　14、Zhang LC, Li N, Liu X, Liang J, Yan H, Zhao KB, Pu L, Shi HB, Zhang YB, Wang LG, Wang LX. A genome-wide association study of limb bone length using a Large White × Minzhu intercross population[J]. Genetics Selection Evolution, 2014, 46(1):56.

　　15、Zhang L, Liang J, Luo W, Liu X, Yan H, Zhao K, Shi H, Zhang Y, Wang L, Wang L. Genome-Wide Scan Reveals LEMD3 and WIF1 on SSC5 as the Candidates for Porcine Ear Size. PLoS ONE, 2014, 9(7):e102085. 2014

　　三、创新团队成员

团队首席：王立贤   执行首席：张龙超

骨干：王立刚、赵福平

助理：刘欣、高红梅、侯欣华、石丽君