一、研究方向：

　　1、畜禽遗传资源收集、多维保护

　　广泛收集国内、国外（巴基斯坦、尼泊尔、孟加拉等畜禽资源丰富的国家）畜禽遗传资源，尤其是特有、珍稀和具潜在利用功能的畜禽资源，构建畜禽资源血液、组织和DNA的样本库，对遗传资源进行表型、分子水平等评价，筛选有重要、潜在引进价值的遗传资源；建立世界规模最大的畜禽遗传资源体细胞库，共计8万余份，覆盖了我国120个重要、濒危品种，开展畜禽遗传资源的细胞保存。

　　2、畜禽遗传资源保存新技术研究

　　研究各类细胞的低温耐受性以及低温损伤机制和预防措施，以期寻找减轻细胞损伤的技术，提高低温保存效果，以保证动物资源长久保存。建立主要畜禽遗传资源共96种类型干细胞的建系、鉴定、保存与诱导技术体系，共计1万余份。

　　3、畜禽遗传资源系统评价和特色畜禽基因资源挖掘

　　对特殊生态地区的畜禽遗传资源（猪、绵羊、山羊等）开展抗逆、抗病、优良性状等方面基因资源挖掘，精准解析畜禽适应性状的遗传机制，为优异基因资源的广泛利用奠定基础。鉴定与发掘家畜生长发育、抗逆等特性的新候选基因30余个，包括家养动物的高海拔低氧适应性和体尺大小南北差异等。

　　二、标志性成果：

　　1、Liu XX (#), Zhang YL (#), Li YF (#), Pan JF, Wang DD, Chen WH, Zheng ZQ, He XH, Zhao QJ, Pu YB, Guan WJ, Han JL, Orlando L*, Ma YH *, Jiang L*. EPAS1 gain-of-function mutation contributes to high-altitude adaptation in Tibetan horses. Molecular Biology and Evolution, 2019, 36(11):2591-2603.

　　2、Wang X (#), Jiang L (#), Wallerman O, Younis S, Yu Q, Klaesson A, Tengholm A, Welsh N, Andersson L. ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells. FASEB Journal. 2019, 33(1):88-100.

　　3、Song S(#), Yang M(#), Li Y, Rouzi M, Zhao Q, Pu Y, He X, Mwacharo JM, Yang N, Ma Y*, Jiang L*. Genome-wide discovery of lincRNAs with spatiotemporal expression patterns in the skin of goat during the cashmere growth cycle. BMC Genomics. 2018, 19(1):495.

　　4、Chunyu Bai(#), Xiangchen Li(#), Yuhua Gao，Ziao Yuan，Pengfei Hu，Hui Wang，Changqing Liu，Weijun Guan*，Yuehui Ma*. Melatonin improves reprogramming efficiency and proliferation of bovine-induced pluripotent stem cells. J Pineal Res. 2016 Sep; 61(2):154-67.

　　5、Yuhua Gao, Chunyu Bai, Dong Zheng, Changli Li, Wenxiu Zhang, Mei Li, Weijun Guan*, Yuehui Ma*. Combination of melatonin and Wnt-4 promotes neural cell differentiation in bovine amniotic epithelial cells and recovery from spinal cord injury, Journal of Pineal Research, 2016, Apr;60(3):303-12  (IF = 9.6)

　　6、Chunyu Bai(#), Xiangchen Li(#), Yuhua Gao(#), Kunfu Wang, Yanan Fan,Shuang Zhang,Yuehui Ma*,Weijun Guan*. Role of microRNA-21 in the formation of insulin-producing cells from pancreatic progenitor cells, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016, 1859(2):280-93.

　　7、Song S(#), Yao N(#), Yang M, Liu X, Dong K, Zhao Q, Pu Y, He X, Guan W, Yang N, Ma Y*, Jiang L*. Exome sequencing reveals genetic differentiation due to high-altitude adaptation in the Tibetan cashmere goat (Capra hircus), BMC Genomics, 2016, 17(1): 122-122.

　　8、Adiljan Kader (#), Yan Li(#), Kunzhe Dong, David M. Irwin, Qianjun Zhao, Xiaohong He, Jianfeng Liu, Yabin Pu, Neena Amatya Gorkhali, Xuexue Liu1, Lin Jiang, Xiangchen Li, Weijun Guan, Yaping Zhang, Dong-Dong Wu*, Yuehui Ma*. Population variation reveals independent selection toward small body size in Chinese Debao pony, Genome Biology and Evolution, 2016, 8(1):42-50.

　　9、Neena Amatya Gorkhali(#), Kunzhe Dong(#), Min Yang, Shen Song, Adiljian Kader, Bhola Shankar Shrestha, Xiaohong He, Qianjun Zhao, Yabin Pu, Xiangchen  Li, James Kijas, Weijun Guan, Jianlin Han, Lin Jiang* & Yuehui  Ma*. Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas. Sci Rep. 2016 Jul 22;6:29963. doi: 10.1038/srep29963.

　　10、Qian Zhao, Ye Kang, Hong-Yang Wang, Wei-Jun Guan, Xiang-Chen Li, Lin Jiang,  Xiao-Hong He, Ya-Bin Pu, Jian-Lin Han, Yue-Hui Ma* & Qian-Jun Zhao*. Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development. Sci Rep. 2016 Jul 25;6:30281. doi: 10.1038/srep30281.

　　三、创新团队成员

团队首席：蒋琳      资深首席：马月辉

骨干：关伟军、赵倩君、何晓红、浦亚斌

助理：胡文萍