一、研究方向:

　　1、 肠道健康与养分高效利用机理

　　研究幼龄反刍动物胃肠道健康发育的营养干预机制，揭示主要营养素在特定时期奶牛体内消化代谢规律及关键调控网络，阐明奶牛泌乳与乳成分高效合成的营养生理与环境应激机制，揭示粪污源抗生素及关键养分在农林牧复合系统的迁徙规律及响应机制。

　　2、 奶牛营养调控与粗饲料高效利用技术

　　研究构建区域特色非常规饲料与新型蛋白质饲料资源高效利用技术、奶牛低碳减排与环境应激缓解技术，研发促进肠道健康的新型外源活性物质干预调控技术，开发改善牛奶品质的营养调控方法与产品。

　　3、 奶牛提质增效技术模式集成示范

　　奶业生产力增长的驱动因素分析，集成构建以“测奶配方”为核心的绿色提质增效生产技术模式。

　　二、代表性成果：

　　1、Gao ST, Ma L, Zhou Z, Zhou ZK, Baumgard LH, Jiang D, Bionaz M, Bu DP: Heat stress negatively affects the transcriptome related to overall metabolism and milk protein synthesis in mammary tissue of midlactating dairy cows. Physiol Genomics 2019, 51(8):400-409.

　　2、Girma DD, Ma L, Wang F, Jiang QR, Callaway TR, Drackley JK, Bu DP: Effects of close-up dietary energy level and supplementing rumen-protected lysine on energy metabolites and milk production in transition cows. J Dairy Sci 2019, 102(8):7059-7072.

　　3、Ma L, Yang Y, Zhao X, Wang F, Gao S, Bu D: Heat stress induces proteomic changes in the liver and mammary tissue of dairy cows independent of feed intake: An iTRAQ study. PLoS One 2019, 14(1):e0209182.

　　4、Pi Y, Ma L, Pierce KM, Wang HR, Xu JC, Bu DP: Rubber seed oil and flaxseed oil supplementation alter digestion, ruminal fermentation and rumen fatty acid profile of dairy cows. Animal 2019:1-10.

　　5、Sun LL, Gao ST, Wang K, Xu JC, Sanz-Fernandez MV, Baumgard LH, Bu DP: Effects of source on bioavailability of selenium, antioxidant status, and performance in lactating dairy cows during oxidative stress-inducing conditions. J Dairy Sci 2019, 102(1):311-319.

　　6、Wang F, van Baal J, Ma L, Loor JJ, Wu ZL, Dijkstra J, Bu DP: Short communication: Relationship between lysine/methionine ratios and glucose levels and their effects on casein synthesis via activation of the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells. J Dairy Sci 2019, 102(9):8127-81336. 

　　7、Ostermann A, Mortimer PE, Huang R, Ma L, Bu D, Xu J: Symbiotic Nitrogen Fixation in Soil Contaminated with the Veterinary Antibiotics Oxytetracycline and Sulfamethazine. J Environ Qual 2019, 48(4):1067-1073.

　　8、Shyam Sundar Paul, Dengpan Bu, Jianchu Xu, Kevin D.Hyde, Zhongtang Yu. A phylogenetic census of global diversity of gut anaerobic fungi and a new taxonomic framework. Fungal Diversity 2018, 89(1): 253–266.

　　9、Gao ST, Guo J, Quan SY, Nan XM, Fernandez MVS, Baumgard LH, Bu DP: The effects of heat stress on protein metabolism in lactating Holstein cows. J Dairy Sci 2017, 100(6):5040-5049.

　　10、Ma L, Zhao M, Zhao LS, Xu JC, Loor JJ, Bu DP: Effects of dietary neutral detergent fiber and starch ratio on rumen epithelial cell morphological structure and gene expression in dairy cows. J Dairy Sci 2017, 100(5):3705-3712.

　　11、Robinson TP, Wertheim HF, Kakkar M, Kariuki S, Bu D, Price LB: Animal production and antimicrobial resistance in the clinic. The Lancet.2016. 387(10014):9-15.

　　12、Robinson TP, Bu DP, Carrique-Mas J, Fevre EM, Gilbert M, Grace D, Hay SI, Jiwakanon J, Kakkar M, Kariuki S et al: Antibiotic resistance is the quintessential One Health issue. Trans R Soc Trop Med Hyg 2016, 110(7):377-380.

　　13、Pi Y, Gao ST, Ma L, Zhu YX, Wang JQ, Zhang JM, Xu JC, Bu DP: Effectiveness of rubber seed oil and flaxseed oil to enhance the alpha-linolenic acid content in milk from dairy cows. J Dairy Sci 2016, 99(7):5719-5730.

　　14、Lian S, Guo JR, Nan XM, Ma L, Loor JJ, Bu DP: MicroRNA Bta-miR-181a regulates the biosynthesis of bovine milk fat by targeting ACSL1. J Dairy Sci 2016, 99(5):3916-3924.

　　15、Zhou XQ, Zhang YD, Zhao M, Zhang T, Zhu D, Bu DP, Wang JQ: Effect of dietary energy source and level on nutrient digestibility, rumen microbial protein synthesis, and milk performance in lactating dairy cows. J Dairy Sci 2015, 98(10):7209-7217.

　　三、创新团队成员

团队首席：卜登攀

骨干：马露

助理：赵连生、吴兆海、詹腾飞